Attention, Grey's Anatomy fans. Your favorite medical drama series is set to return with a brand-new season very soon on ABC. No, you didn't read that wrong. Grey's Anatomy will be back in October. After that season 21 cliffhanger ending that had everyone talking for weeks, we're sure you're more eager than ever to see what’s next for all of your favorite doctors at Grey Sloan Memorial.
In this ultimate guide provided below, we’ve got everything you need to know before the premiere. We're talking the exact date you’ll want to mark on your calendar, who you can expect to see return, and many other juicy updates.
When does Grey's Anatomy return?
Grey's Anatomy season 22 is scheduled to have its premiere on ABC on Thursday, Oct. 9, 2025, at 10/9c. It was originally supposed to air a week later on Oct. 16, but the network decided to move up the premiere date. However, it's unclear why ABC decided to make this decision. We're not complaining, though, because that just means we get to see the new season even sooner!
The twenty-second installment is set to air after 911 season 9 and 911: Nashville. 911 season 9 will kick off the night at 8/7c, followed by the premiere of 911: Nashville at 9/8c and then Grey's Anatomy season 22 at 10/9c. If you miss the premiere, you can stream the episode the following day on Hulu. The same goes for future episodes as well.
When is Grey's Anatomy on?
After Grey's Anatomy season 22 premieres, you can expect a brand-new episode to air every Thursday night at 10/9c on ABC. In other words, you don't have to worry about a change in schedule once the season kicks off. Grey’s Anatomy season 22 is expected to consistently air in its Thursday night slot, making it easy for you to keep up with every new episode week after week.
Where can you catch up on Grey's Anatomy?
Let’s say you still haven’t watched the previous season, or maybe you just want a refresher. Now’s the perfect time to catch up on past episodes, so you’ll be fully ready when the new season premieres. How? Well, there are multiple ways you can watch the medical drama. First, you can either stream it on Hulu or Netflix. Both streaming services are home to all previous 21 seasons of Grey's Anatomy. However, keep in mind that you'll need to be subscribed to these streamers in order to be granted access.
Alternatively, you can purchase individual episodes or entire seasons through digital platforms like Amazon Prime Video, Fandango at Home, Google Play, and others. The choice is ultimately up to you!
Who could be in the Grey's Anatomy season 22 cast?
So, here's the thing about the Grey's Anatomy season 22 cast. An official cast list has not been revealed. The only confirmed cast members are Ellen Pompeo (Meredith Grey), Caterina Scorsone (Amelia Shepherd), Anthony Hill (Winston Ndugu), and Alexis Floyd (Simone Griffith). All of these characters appear in the new Grey's Anatomy season 22 production stills that ABC released in early September. Trevor Jackson, who joined the medical drama last season, is also confirmed to return, as evidenced by his appearance in one of the new photos.
Camilla Luddington, who portrays Jo Wilson, is basically confirmed to return as well after she spoke about the filming process for season 22 in an interview with E! News back in August 2025. The rest of the main cast is also expected to come back given they've signed contracts extending into season 22.
We shared a list below of the cast members who are expected to return:
- Chandra Wilson as Miranda Bailey
- James Pickins Jr. as Richard Webber
- Kevin McKidd as Owen Hunt
- Kim Raver as Teddy Altman
- Jason George as Ben Warren
- Chris Carmack as Atticus “Link” Lincoln
- Harry Shum Jr. as Benson “Blue” Kwan
- Adelaide Kane as Jules Millin
- Niko Terho as Lucas Adams
Grey's Anatomy showrunner Meg Marinis shared in an interview with TVLine that some characters from previous seasons will also make an appearance in the twenty-second installment. Although she did not give any names, we've already started speculating who they can be. We hope one of those characters is Mika, who was played by Midori Francis. Mika left Grey Sloan in the first half of season 21. She and Jules still have some unfinished business, and we'd like to see how things play out.
How did Grey's Anatomy season 21 end?
While different doctors were around the hospital tending to their patients, the season 21 finale mainly focused on a desperate mother who, fearing for her daughter’s survival, resorted to extreme measures to force the doctors to continue operating on her. Her actions escalated into a tense hostage-like situation, with Amelia, Simone, and other staff caught in the middle.
Although the girl pulls through after a successful operation, chaos erupts when the highly flammable acetylene tank the mother used to threaten the doctors topples over, triggering an explosion that engulfs the entire OR floor in flames. Those on the OR floor at the time were Link, Monica, Miranda, and Jules. While they're all the most at risk, Marinis shared in a recent interview that anyone in the hospital at the time of the explosion is in danger.
Here are more important things that happen in the season 21 finale:
- Owen and Teddy’s relationship hits a breaking point. Witnessing Owen’s deep bond with Nora, Teddy realizes she can’t continue their marriage and chooses to prioritize herself rather than remain in a relationship where she doesn't feel appreciated.
- Simone and Luca reconcile, but Simone is then placed in a weird situation when the guy she hooked up with behind Lucas's back turns out to be a new intern at the hospital.
- Jo reveals to Link that they're having twin girls.
- Meredith strikes a deal with Catherine that allows her to spend her summers in Seattle working at Grey Sloan, while also still being able to pursue her Alzheimer's research.
Although an official synopsis for the Grey's Anatomy season 22 premiere hasn't been revealed, the new installment is expected to pick up right after the explosion. It'll be interesting to see which characters survive and how the hospital recovers from such a devastating situation.
Stay tuned to GeekSided for more information on Grey's Anatomy season 22.